CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family Acetyl-CoA acetyltransferase

Enzyme Information

2.3.1.9
Acetyl-CoA C-acetyltransferase.
based on mapping to UniProt Q18AR0
2 acetyl-CoA = CoA + acetoacetyl-CoA.
-!- The enzyme, found in both eukaryotes and prokaryotes, catalyzes the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. -!- The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. -!- In the second step the acyl group is transferred to an acetyl-CoA molecule. -!- Cf. EC 2.3.1.16.

UniProtKB Entries (1)

Q18AR0
THLA_PEPD6
Clostridioides difficile 630
Acetyl-CoA acetyltransferase

PDB Structure

PDB 4DD5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biosynthetic Thiolase (ThlA1) from Clostridium difficile
Filippova, E.V., Wawrzak, Z., Kudritska, M., Edwards, A., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
To be Published