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1 keywords

CATH Domain 4d0tE01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.550 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homologous Superfamily 3.90.550.10 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family Polypeptide N-acetylgalactosaminyltransferase

Enzyme Information

2.4.1.41
Polypeptide N-acetylgalactosaminyltransferase.
based on mapping to UniProt Q10471
(1) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine. (2) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine.
-!- The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.

UniProtKB Entries (1)

Q10471
GALT2_HUMAN
Homo sapiens
Polypeptide N-acetylgalactosaminyltransferase 2

PDB Structure

PDB 4D0T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2.
Lira-Navarrete, E., Iglesias-Fernandez, J., Zandberg, W.F., Companon, I., Kong, Y., Corzana, F., Pinto, B.M., Clausen, H., Peregrina, J.M., Vocadlo, D., Rovira, C., Hurtado-Guerrero, R.
Angew.Chem.Int.Ed.Engl.
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