CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.360
Functional Family NAD(P)H dehydrogenase [quinone] 1

Enzyme Information

1.6.5.2
NAD(P)H dehydrogenase (quinone).
based on mapping to UniProt P15559
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
-!- The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. -!- The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. -!- Formerly EC 1.6.99.2.

UniProtKB Entries (1)

P15559
NQO1_HUMAN
Homo sapiens
NAD(P)H dehydrogenase [quinone] 1

PDB Structure

PDB 4CET
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Collapse of the Native Structure by a Single Amino Acid Exchange in Human Nad(P)H:Quinone Oxidoreductase (Nqo1).
Lienhart, W.-D., Gudipati, V., Uhl, M.K., Binter, A., Pulido, S., Saf, R., Zangger, K., Gruber, K., Macheroux, P.
FEBS J.