CATH Domain 4aw5A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Ephrin type-B receptor 2

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P54760

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P54760

EPHB4_HUMAN

Homo sapiens

Ephrin type-B receptor 4

PDB Structure

PDB	4AW5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Design, Synthesis, and Biological Evaluation of Potent Receptor Tyrosine Kinase Inhibitors. Kim, M.H., Tsuhako, A.L., Co, E.W., Aftab, D.T., Bentzien, F., Chen, J., Cheng, W., Engst, S., Goon, L., Klein, R.R., Le, D.T., Mac, M., Parks, J.J., Qian, F., Rodriquez, M., Stout, T.J., Till, J.H., Won, K.A., Wu, X., Michael Yakes, F., Yu, P., Zhang, W., Zhao, Y., Lamb, P., Nuss, J.M., Xu, W. Bioorg.Med.Chem.Lett.