CATH Classification
Domain Context
CATH Clusters
Superfamily | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
Functional Family | L-lactate dehydrogenase A chain |
Enzyme Information
1.1.1.27 |
L-lactate dehydrogenase.
based on mapping to UniProt P04642
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
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UniProtKB Entries (1)
P04642 |
LDHA_RAT
Rattus norvegicus
L-lactate dehydrogenase A chain
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PDB Structure
PDB | 4AJI |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation
J.Med.Chem.
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