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1 keywords

CATH Domain 4ae8A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.10 Roll
Topology 3.10.129 Thiol Ester Dehydrase; Chain A
Homologous Superfamily 3.10.129.10 Hotdog Thioesterase

Domain Context

CATH Clusters

Superfamily Hotdog Thioesterase
Functional Family Acyl-coenzyme A thioesterase THEM4

Enzyme Information

3.1.2.2
Palmitoyl-CoA hydrolase.
based on mapping to UniProt Q5T1C6
Palmitoyl-CoA + H(2)O = CoA + palmitate.
-!- Also hydrolyzes CoA thioesters of other long-chain fatty acids.

UniProtKB Entries (1)

Q5T1C6
THEM4_HUMAN
Homo sapiens
Acyl-coenzyme A thioesterase THEM4

PDB Structure

PDB 4AE8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Acyl Coenzyme a Thioesterase Them5/Acot15 is Involved in Cardiolipin Remodeling and Fatty Liver Development.
Zhuravleva, E., Gut, H., Hynx, D., Marcellin, D., Bleck, C.K.E., Genoud, C., Cron, P., Keusch, J.J., Dummler, B., Esposti, M.D., Hemmings, B.A.
Mol.Cell.Biol.
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