×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

1 keywords

CATH Domain 4a6dA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Acetylserotonin O-methyltransferase

Enzyme Information

2.1.1.4
Acetylserotonin O-methyltransferase.
based on mapping to UniProt P46597
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
-!- Some other hydroxyindoles also act as acceptor, more slowly.

UniProtKB Entries (1)

P46597
ASMT_HUMAN
Homo sapiens
Acetylserotonin O-methyltransferase

PDB Structure

PDB 4A6D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway.
Botros, H.G., Legrand, P., Pagan, C., Bondet, V., Weber, P., Ben-Abdallah, M., Lemiere, N., Huguet, G., Bellalou, J., Maronde, E., Beguin, P., Haouz, A., Shepard, W., Bourgeron, T.
J.Pineal Res.
CATH-Gene3D is a Global Biodata Core Resource Learn more...