CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family Ectonucleoside triphosphate diphosphohydrolase 1

Enzyme Information

3.6.1.5
Apyrase.
based on mapping to UniProt P97687
A nucleoside 5'-triphosphate + 2 H(2)O = a nucleoside 5'-phosphate + 2 phosphate.
-!- Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. -!- They differ from ATPases, which specifically hydrolyze ATP, by hydrolyzing both ATP and ADP. -!- Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this enzyme family.

UniProtKB Entries (1)

P97687
ENTP1_RAT
Rattus norvegicus
Ectonucleoside triphosphate diphosphohydrolase 1

PDB Structure

PDB 3ZX3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic Evidence for a Domain Motion in Rat Nucleoside Triphosphate Diphosphohydrolase (Ntpdase) 1.
Zebisch, M., Krauss, M., Schafer, P., Strater, N.
J.Mol.Biol.