CATH Classification

Domain Context

CATH Clusters

Superfamily Haem peroxidase domain superfamily, animal type
Functional Family Myeloperoxidase

Enzyme Information

1.11.2.2
Myeloperoxidase.
based on mapping to UniProt P05164
Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O.
-!- Is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. -!- It differs from EC 1.11.1.10 in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). -!- Hypochlorite in turn forms a number of antimicrobial products (Cl(2), chloramines, hydroxyl radical, singlet oxygen). -!- MPO also oxidizes bromide, iodide and thiocyanate. -!- In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.

UniProtKB Entries (1)

P05164
PERM_HUMAN
Homo sapiens
Myeloperoxidase

PDB Structure

PDB 3ZS1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation.
Tiden, A.K., Sjogren, T., Svensson, M., Bernlind, A., Senthilmohan, R., Auchere, F., Norman, H., Markgren, P.O., Gustavsson, S., Schmidt, S., Lundquist, S., Forbes, L.V., Magon, N.J., Paton, L.N., Jameson, G.N., Eriksson, H., Kettle, A.J.
J.Biol.Chem.