CATH Domain 3zrfF02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.750	Elongin C; Chain C, domain 1
	1.10.750.10	von Hippel-Lindau disease tumour suppressor, alpha domain

Domain Context

CATH Clusters

Superfamily	von Hippel-Lindau disease tumour suppressor, alpha domain
Functional Family	von Hippel-Lindau disease tumor suppressor

Enzyme Information

UniProtKB Entries (1)

VHL_HUMAN

Homo sapiens

Von Hippel-Lindau disease tumor suppressor

PDB Structure

PDB	3ZRF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction Buckley, D.L., Van Molle, I., Gareiss, P.C., Tae, H.S., Michel, J., Noblin, D.J., Jorgensen, W.L., Ciulli, A., Crews, C.M. J.Am.Chem.Soc.