CATH Classification

Domain Context

CATH Clusters

Superfamily Copper amine oxidase, catalytic domain
Functional Family Amine oxidase

Enzyme Information
Primary-amine oxidase.
based on mapping to UniProt P46881
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC

UniProtKB Entries (1)

Arthrobacter globiformis
Phenylethylamine oxidase

PDB Structure

PDB 3X41
External Links
Primary Citation
Probing the Catalytic Mechanism of Copper Amine Oxidase from Arthrobacter globiformis with Halide Ions.
Murakawa, T., Hamaguchi, A., Nakanishi, S., Kataoka, M., Nakai, T., Kawano, Y., Yamaguchi, H., Hayashi, H., Tanizawa, K., Okajima, T.