CATH Domain 3vxgA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.100	NADP-dependent oxidoreductase domain

Domain Context

CATH Clusters

Superfamily	NADP-dependent oxidoreductase domain
Functional Family

Enzyme Information

1.1.1.358	2-dehydropantolactone reductase. based on mapping to UniProt Q76L36 (R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH. -!- The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B(5)). -!- This entry covers enzymes whose stereo specificity for NADP(+) is not known (cf. EC 1.1.1.168 and EC 1.1.1.214).
1.1.1.168	2-dehydropantolactone reductase (Re-specific). based on mapping to UniProt Q76L36 (R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH. -!- The enzyme from Saccharomyces cerevisiae differs from that from Escherichia coli (EC 1.1.1.214), which is specific for the Si-face of NADP, and in receptor requirements from EC 1.1.99.26.

UniProtKB Entries (1)

CPRC2_CANPA

Candida parapsilosis

NADPH-dependent conjugated polyketone reductase C2

PDB Structure

PDB	3VXG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of conjugated polyketone reductase from Candida parapsilosis IFO 0708 reveals conformational changes for substrate recognition upon NADPH binding Qin, H.-M., Yamamura, A., Miyakawa, T., Kataoka, M., Nagai, T., Kitamura, N., Urano, N., Maruoka, S., Ohtsuka, J., Nagata, K., Shimizu, S., Tanokura, M. Appl.Microbiol.Biotechnol.