CATH Domain 3vr4C03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.100	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain Context

CATH Clusters

Superfamily	2.40.50.100
Functional Family	V-type proton ATPase catalytic subunit A

Enzyme Information

7.2.2.1

Na(+)-transporting two-sector ATPase.

based on mapping to UniProt Q08636

ATP + H(2)O + n Na(+)(Side 1) = ADP + phosphate + n Na(+)(Side 2).

-!- A multisubunit ATPase transporter found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis. -!- The enzyme is similar to EC 7.1.2.2 but pumps Na(+) rather than H(+). -!- Cf. EC 7.2.2.3 and EC 7.2.2.4. -!- Formerly EC 3.6.3.15.

UniProtKB Entries (1)

Q08637

NTPB_ENTHA

Enterococcus hirae ATCC 9790

V-type sodium ATPase subunit B

PDB Structure

PDB	3VR4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Rotation mechanism of Enterococcus hirae V(1)-ATPase based on asymmetric crystal structures Arai, S., Saijo, S., Suzuki, K., Mizutani, K., Kakinuma, Y., Ishizuka-Katsura, Y., Ohsawa, N., Terada, T., Shirouzu, M., Yokoyama, S., Iwata, S., Yamato, I., Murata, T. Nature

Network disruptions