CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.40 | ATPase, nucleotide binding domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.420.40 |
| Functional Family | nebramycin 5' synthase |
Enzyme Information
| 6.1.2.2 |
Nebramycin 5' synthase.
based on mapping to UniProt Q70IY1
(1) Tobramycin + carbamoyl phosphate + ATP + H(2)O = nebramycin 5' + AMP + diphosphate + phosphate. (2) Kanamycin A + carbamoyl phosphate + ATP + H(2)O = 6''-O- carbamoylkanamycin A + AMP + diphosphate + phosphate.
-!- The enzyme from the bacterium Streptoalloteichus tenebrarius catalyzes the activation of carbamoyl phosphate to O-carbamoyladenylate and the subsequent carbamoylation of kanamycin and tobramycin. -!- Formerly EC 2.1.3.13 and EC 2.1.3.14.
|
UniProtKB Entries (1)
| Q70IY1 |
TOBZ_STRSD
Streptoalloteichus tenebrarius
Nebramycin 5' synthase
|
PDB Structure
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| Primary Citation |
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