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CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

4.1.1.48
Indole-3-glycerol-phosphate synthase.
based on mapping to UniProt Q06121
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

Q06121
TRPC_SACS2
Saccharolobus solfataricus P2
Indole-3-glycerol phosphate synthase

PDB Structure

PDB 3TC7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design.
Bjelic, S., Kipnis, Y., Wang, L., Pianowski, Z., Vorobiev, S., Su, M., Seetharaman, J., Xiao, R., Kornhaber, G., Hunt, J.F., Tong, L., Hilvert, D., Baker, D.
J.Mol.Biol.
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