CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotidyltransferases domain 2
Functional Family focal adhesion kinase 1 isoform X1

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q05397
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q05397
FAK1_HUMAN
Homo sapiens
Focal adhesion kinase 1

PDB Structure

PDB 3S9O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells.
Kadare, G., Gervasi, N., Brami-Cherrier, K., Blockus, H., El Messari, S., Arold, S.T., Girault, J.A.
J.Biol.Chem.