CATH Domain 3s2uA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.2000	Glycogen Phosphorylase B;

Domain Context

CATH Clusters

Superfamily	Glycogen Phosphorylase B;
Functional Family

Enzyme Information

2.4.1.227

Undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase.

based on mapping to UniProt Q9HW01

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

-!- The enzyme also works when the lysine residue is replaced by meso- 2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-center, as it is in Gram- negative and some Gram-positive organisms. -!- The undecaprenol involved is ditrans,octacis-undecaprenol.

UniProtKB Entries (1)

Q9HW01

MURG_PSEAE

Pseudomonas aeruginosa PAO1

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

PDB Structure

PDB	3S2U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the Pseudomonas aeruginosa MurG: UDP-GlcNAc Substrate Complex. Brown, K., Vial, S.C., Dedi, N., Westcott, J., Scally, S., Bugg, T.D., Charlton, P.A., Cheetham, G.M. Protein Pept.Lett.