CATH Domain 3rjwB00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.270	Beta-clip-like
	2.170.270.10	SET domain

Domain Context

CATH Clusters

Superfamily	SET domain
Functional Family	Euchromatic histone-lysine N-methyltransferase 2

Enzyme Information

2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q96KQ7 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-	Methyltransferases. based on mapping to UniProt Q96KQ7

UniProtKB Entries (1)

EHMT2_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase EHMT2

PDB Structure

PDB	3RJW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Vedadi, M., Barsyte-Lovejoy, D., Liu, F., Rival-Gervier, S., Allali-Hassani, A., Labrie, V., Wigle, T.J., Dimaggio, P.A., Wasney, G.A., Siarheyeva, A., Dong, A., Tempel, W., Wang, S.C., Chen, X., Chau, I., Mangano, T.J., Huang, X.P., Simpson, C.D., Pattenden, S.G., Norris, J.L., Kireev, D.B., Tripathy, A., Edwards, A., Roth, B.L., Janzen, W.P., Garcia, B.A., Petronis, A., Ellis, J., Brown, P.J., Frye, S.V., Arrowsmith, C.H., Jin, J. Nat.Chem.Biol.