CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Protein kinase C

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt P68403
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P68403
KPCB_RAT
Rattus norvegicus
Protein kinase C beta type

PDB Structure

PDB 3PFQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure and Allosteric Activation of Protein Kinase C beta II
Leonard, T.A., Rozycki, B., Saidi, L.F., Hummer, G., Hurley, J.H.
Cell(Cambridge,Mass.)