CATH Domain 3p5jA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	Ribonuclease

Enzyme Information

3.1.26.4

Ribonuclease H.

based on mapping to UniProt Q9CWY8

Endonucleolytic cleavage to 5'-phosphomonoester.

-!- Acts on RNA-DNA hybrids.

UniProtKB Entries (1)

RNH2A_MOUSE

Mus musculus

Ribonuclease H2 subunit A

PDB Structure

PDB	3P5J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease. Reijns, M.A., Bubeck, D., Gibson, L.C., Graham, S.C., Baillie, G.S., Jones, E.Y., Jackson, A.P. J.Biol.Chem.