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1 keywords

CATH Domain 3p5bA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.200 Peptidase S8/S53 domain

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-
Serine endopeptidases.
based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

Q8NBP7
PCSK9_HUMAN
Homo sapiens
Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB 3P5B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y.G., Hubbard, B., Sitlani, A., Carfi, A.
Embo Rep.
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