CATH Classification

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family cGMP-dependent protein kinase

Enzyme Information
cGMP-dependent protein kinase.
based on mapping to UniProt Q13976
ATP + a protein = ADP + a phosphoprotein.
-!- cGMP is required to activate this enzyme. -!- The enzyme occurs as a dimer in higher eukaryotes. -!- The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. -!- This domain catalyzes the phosphorylation by ATP to specific serine or threonine residues in protein substrates. -!- The enzyme also has two allosteric cGMP-binding sites (sites A and B). -!- Binding of cGMP causes a conformational change that is associated with activation of the kinase. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
CGMP-dependent protein kinase 1

PDB Structure

External Links
Primary Citation
Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Kim, J.J., Casteel, D.E., Huang, G., Kwon, T.H., Ren, R.K., Zwart, P., Headd, J.J., Brown, N.G., Chow, D.C., Palzkill, T., Kim, C.
Plos One