CATH Domain 3nkuA00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.357	Tetracycline Repressor; domain 2
	1.10.357.170

Domain Context

CATH Clusters

Superfamily	1.10.357.170
Functional Family

Enzyme Information

2.7.7.n6	Guanine phosphate-protein transferase. based on mapping to UniProt Q29ST3 GTP + [protein]-L-tyrosine = diphosphate + [protein]-O(4)-(5'-guanylyl)- L-tyrosine. -!- The enzyme from Legionella also functions as EC 2.7.7.n1.
2.7.7.n1	Protein adenylyltransferase. based on mapping to UniProt Q29ST3 (1) ATP + [protein]-L-tyrosine = diphosphate + [protein]-O(4)- (5'-adenylyl)-L-tyrosine. (2) ATP + [protein]-L-threonine = diphosphate + [protein]-O(4)- (5'-adenylyl)-L-threonine.

UniProtKB Entries (1)

DRRA_LEGPN

Legionella pneumophila

Multifunctional virulence effector protein DrrA

PDB Structure

PDB	3NKU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Muller, M.P., Peters, H., Blumer, J., Blankenfeldt, W., Goody, R.S., Itzen, A. Science