CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Putative cyclin-dependent kinase 17

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q00536
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q00536
CDK16_HUMAN
Homo sapiens
Cyclin-dependent kinase 16

PDB Structure

PDB 3MTL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A.
to be published