CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P43166
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P43166
CAH7_HUMAN
Homo sapiens
Carbonic anhydrase 7

PDB Structure

PDB 3ML5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide
Di Fiore, A., Truppo, E., Supuran, C.T., Alterio, V., Dathan, N., Bootorabi, F., Parkkila, S., Monti, S.M., De Simone, G.
Bioorg.Med.Chem.Lett.