CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase pim-1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P11309
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P11309
PIM1_HUMAN
Homo sapiens
Serine/threonine-protein kinase pim-1

PDB Structure

PDB 3MA3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.
Lopez-Ramos, M., Prudent, R., Moucadel, V., Sautel, C.F., Barette, C., Lafanechere, L., Mouawad, L., Grierson, D., Schmidt, F., Florent, J.C., Filippakopoulos, P., Bullock, A.N., Knapp, S., Reiser, J.B., Cochet, C.
Faseb J.