CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.520.10
Functional Family

Enzyme Information

1.11.1.13
Manganese peroxidase.
based on mapping to UniProt Q02567
2 Mn(2+) + 2 H(+) + H(2)O(2) = 2 Mn(3+) + 2 H(2)O.
-!- The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. -!- The enzyme oxidizes a bound Mn(2+) ion to Mn(3+) in the presence of hydrogen peroxide. -!- The product, Mn(3+), is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn(2+) and insoluble Mn(4+). -!- The complexed Mn(3+) ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates. -!- It is inactive with veratryl alcohol or nonphenolic substrates.

UniProtKB Entries (1)

Q02567
PEM1_PHACH
Phanerochaete chrysosporium
Manganese peroxidase 1

PDB Structure

PDB 3M8M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ultrahigh (0.93A) resolution structure of manganese peroxidase from Phanerochaete chrysosporium: implications for the catalytic mechanism.
Sundaramoorthy, M., Gold, M.H., Poulos, T.L.
J.Inorg.Biochem.