CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase C15, pyroglutamyl peptidase I-like
Functional Family Pyrrolidone-carboxylate peptidase

Enzyme Information

3.4.19.3
Pyroglutamyl-peptidase I.
based on mapping to UniProt Q81NT5
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.
-!- Removes 5-oxoproline from various penultimate amino acid residues except L-proline. -!- Inhibited by thiol-blocking reagents. -!- Belongs to peptidase family C15. -!- Formerly EC 3.4.11.8.

UniProtKB Entries (1)

Q81NT5
PCP_BACAN
Bacillus anthracis
Pyrrolidone-carboxylate peptidase

PDB Structure

PDB 3LAC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Bacillus anthracis pyrrolidone-carboxylate peptidase, pcP
Anderson, S.M., Wawrzak, Z., Onopriyenko, O., Hasseman, J., Edwards, A., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
To be Published