CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit alpha

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P17612
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P17612
KAPCA_HUMAN
Homo sapiens
CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB 3L9L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Zeng, Q., Allen, J.G., Bourbeau, M.P., Wang, X., Yao, G., Tadesse, S., Rider, J.T., Yuan, C.C., Hong, F.T., Lee, M.R., Zhang, S., Lofgren, J.A., Freeman, D.J., Yang, S., Li, C., Tominey, E., Huang, X., Hoffman, D., Yamane, H.K., Fotsch, C., Dominguez, C., Hungate, R., Zhang, X.
Bioorg.Med.Chem.Lett.