CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate/ornithine carbamoyltransferase
Functional Family

Enzyme Information

2.1.3.9
N-acetylornithine carbamoyltransferase.
based on mapping to UniProt Q8P8J2
Carbamoyl phosphate + N(2)-acetyl-L-ornithine = phosphate + N-acetyl-L- citrulline.
-!- Differs from EC 2.1.3.3. -!- This enzyme replaces EC 2.1.3.3 in the canonic arginine biosynthetic pathway of several eubacteria and has no catalytic activity with L-ornithine as substrate.

UniProtKB Entries (1)

Q8P8J2
AOTC_XANCP
Xanthomonas campestris pv. campestris str. ATCC 33913
N-acetylornithine carbamoyltransferase

PDB Structure

PDB 3L05
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase.
Shi, D., Yu, X., Cabrera-Luque, J., Chen, T.Y., Roth, L., Morizono, H., Allewell, N.M., Tuchman, M.
Protein Sci.