CATH Domain 3ktzB02

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.470	Ricin (A Subunit), domain 2
	4.10.470.10	Ricin (A Subunit), domain 2

Domain Context

CATH Clusters

Superfamily	Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P33186

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P33186

RIPG_SURMU

Suregada multiflora

Ribosome-inactivating protein gelonin

PDB Structure

PDB	3KTZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A new activity of anti-HIV and anti-tumor protein GAP31: DNA adenosine glycosidase--structural and modeling insight into its functions. Li, H.G., Huang, P.L., Zhang, D., Sun, Y., Chen, H.C., Zhang, J., Huang, P.L., Kong, X.P., Lee-Huang, S. Biochem.Biophys.Res.Commun.

Network disruptions