CATH Domain 3kjsC02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q8T5T8_TRYCR

Trypanosoma cruzi

Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB	3KJS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase. Schormann, N., Velu, S.E., Murugesan, S., Senkovich, O., Walker, K., Chenna, B.C., Shinkre, B., Desai, A., Chattopadhyay, D. Bioorg.Med.Chem.