CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleic acid-binding proteins
Functional Family DNA helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P53091
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P40359
PSF2_YEAST
Saccharomyces cerevisiae S288C
DNA replication complex GINS protein PSF2

PDB Structure

PDB 3JC6
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Yuan, Z., Bai, L., Sun, J., Georgescu, R., Liu, J., O'Donnell, M.E., Li, H.
Nat.Struct.Mol.Biol.