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1 keywords

CATH Domain 3isqA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.10 Roll
Topology 3.10.180 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1
Homologous Superfamily 3.10.180.10 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1

Domain Context

CATH Clusters

Superfamily 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
Functional Family 4-hydroxyphenylpyruvate dioxygenase

Enzyme Information

1.13.11.27
4-hydroxyphenylpyruvate dioxygenase.
based on mapping to UniProt P32754
4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).
-!- Formerly EC 1.14.2.2 and EC 1.99.1.14.

UniProtKB Entries (1)

P32754
HPPD_HUMAN
Homo sapiens
4-hydroxyphenylpyruvate dioxygenase

PDB Structure

PDB 3ISQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase
Pilka, E.S., Shafqat, N., Cocking, R., Bray, J.E., Krojer, T., Pike, A.C.W., von Delft, F., Yue, W.W., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U., Kavanagh, K.L.
to be published
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