CATH Domain 3ip0A00
|Functional Family||2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase|
based on mapping to UniProt P26281
ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8- dihydropterin diphosphate.
-!- The enzyme participates in the pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). -!- The enzyme exists in varying types of multifunctional proteins in different organisms. -!- The enzyme from the bacterium Streptococcus pneumoniae also harbors the activity of EC 220.127.116.11, the enzyme from the plant Arabidopsis thaliana harbors the activity of EC 18.104.22.168, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities.
UniProtKB Entries (1)
Escherichia coli K-12
Dynamic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydroptein pyrophosphokinase: Crystallographic studies