CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Transitional endoplasmic reticulum ATPase

Enzyme Information

3.6.4.6
Vesicle-fusing ATPase.
based on mapping to UniProt P55072
ATP + H(2)O = ADP + phosphate.
-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (1)

P55072
TERA_HUMAN
Homo sapiens
Transitional endoplasmic reticulum ATPase

PDB Structure

PDB 3HU3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.
Tang, W.K., Li, D., Li, C.C., Esser, L., Dai, R., Guo, L., Xia, D.
Embo J.