CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.10 | Ribonuclease H-like superfamily/Ribonuclease H |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease H-like superfamily/Ribonuclease H |
| Functional Family |
Enzyme Information
| 3.1.3.73 |
Adenosylcobalamin/alpha-ribazole phosphatase.
based on mapping to UniProt P9WLH5
(1) Adenosylcobalamin 5'-phosphate + H(2)O = coenzyme B12 + phosphate. (2) Alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate.
-!- This enzyme catalyzes the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica. -!- It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin.
|
| 3.1.26.4 |
Ribonuclease H.
based on mapping to UniProt P9WLH5
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
|
UniProtKB Entries (2)
| P9WLH5 |
RNHPH_MYCTU
Mycobacterium tuberculosis H37Rv
Bifunctional protein Rv2228c
|
| P0AEX9 |
MALE_ECOLI
Escherichia coli K-12
Maltose/maltodextrin-binding periplasmic protein
|
PDB Structure
| PDB | 3HST |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis.
J.Bacteriol.
|
