CATH Domain 3hrhB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Diacylglycerol acyltransferase/mycolyltransferase Ag85C

Enzyme Information

2.3.1.122	Trehalose O-mycolyltransferase. based on mapping to UniProt P9WQN9 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate. -!- Catalyzes the exchange of mycolic acid between trehalose, trehalose mycolate and trehalose bismycolate. -!- Trehalose 6-palmitate can also act as donor.
2.3.1.20	Diacylglycerol O-acyltransferase. based on mapping to UniProt P9WQN9 Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. -!- Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

UniProtKB Entries (1)

A85C_MYCTU

Mycobacterium tuberculosis H37Rv

Diacylglycerol acyltransferase/mycolyltransferase Ag85C

PDB Structure

PDB	3HRH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C. Sanki, A.K., Boucau, J., Umesiri, F.E., Ronning, D.R., Sucheck, S.J. Mol Biosyst