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1 keywords

CATH Domain 3hlcA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.710 Beta-lactamase
Homologous Superfamily 3.40.710.10 DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

2.3.1.238
Monacolin J acid methylbutanoate transferase.
based on mapping to UniProt Q9Y7D1
Monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] = lovastatin acid + [2-methylbutanoate polyketide synthase].
-!- The enzyme catalyzes the ultimate reaction in the lovastatin biosynthesis pathway of the filamentous fungus Aspergillus terreus.

UniProtKB Entries (1)

Q9Y7D1
LOVD_ASPTE
Aspergillus terreus
Monacolin J acid methylbutanoyltransferase

PDB Structure

PDB 3HLC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Directed evolution and structural characterization of a simvastatin synthase
Gao, X., Xie, X., Pashkov, I., Sawaya, M.R., Laidman, J., Zhang, W., Cacho, R., Yeates, T.O., Tang, Y.
Chem.Biol.
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