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1 keywords

CATH Domain 3hkiD00

CATH Classification

Level CATH Code Description
Class 4 Few Secondary Structures
Architecture 4.10 Irregular
Topology 4.10.140 Epsilon-Thrombin; Chain L
Homologous Superfamily 4.10.140.10 Thrombin light chain domain

Domain Context

CATH Clusters

Superfamily Thrombin light chain domain
Functional Family

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P19221
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P19221
THRB_MOUSE
Mus musculus
Prothrombin
P25116
PAR1_HUMAN
Homo sapiens
Proteinase-activated receptor 1

PDB Structure

PDB 3HKI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A.
Gandhi, P.S., Page, M.J., Chen, Z., Bush-Pelc, L., Di Cera, E.
J.Biol.Chem.
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