1 keywords

CATH Domain 3he2A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.226 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous Superfamily 3.90.226.10 2-enoyl-CoA Hydratase; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family Probable enoyl-CoA hydratase echA6

Enzyme Information

4.2.1.17
Enoyl-CoA hydratase.
based on mapping to UniProt P9WNP1
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.
-!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).

UniProtKB Entries (1)

P9WNP1
ECHA6_MYCTU
Mycobacterium tuberculosis H37Rv
Probable enoyl-CoA hydratase echA6

PDB Structure

PDB 3HE2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Increasing the structural coverage of tuberculosis drug targets.
Baugh, L., Phan, I., Begley, D.W., Clifton, M.C., Armour, B., Dranow, D.M., Taylor, B.M., Muruthi, M.M., Abendroth, J., Fairman, J.W., Fox, D., Dieterich, S.H., Staker, B.L., Gardberg, A.S., Choi, R., Hewitt, S.N., Napuli, A.J., Myers, J., Barrett, L.K., Zhang, Y., Ferrell, M., Mundt, E., Thompkins, K., Tran, N., Lyons-Abbott, S., Abramov, A., Sekar, A., Serbzhinskiy, D., Lorimer, D., Buchko, G.W., Stacy, R., Stewart, L.J., Edwards, T.E., Van Voorhis, W.C., Myler, P.J.
Tuberculosis (Edinb)