CATH Domain 3hbbC01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.430	Dihydrofolate Reductase, subunit A
	3.40.430.10	Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily	Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

2.1.1.45	Thymidylate synthase. based on mapping to UniProt Q27793 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
1.5.1.3	Dihydrofolate reductase. based on mapping to UniProt Q27793 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH. -!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

DRTS_TRYCR

Trypanosoma cruzi

Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB	3HBB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate. Senkovich, O., Schormann, N., Chattopadhyay, D. Acta Crystallogr.,Sect.D