CATH Domain 3gymA01

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Tryptase beta-2

Enzyme Information

3.4.21.-

Serine endopeptidases.

based on mapping to UniProt Q16651

UniProtKB Entries (2)

Q16651	PRSS8_HUMAN Homo sapiens Prostasin
P00974	BPT1_BOVIN Bos taurus Pancreatic trypsin inhibitor

PDB Structure

PDB	3GYM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Spraggon, G., Hornsby, M., Shipway, A., Tully, D.C., Bursulaya, B., Danahay, H., Harris, J.L., Lesley, S.A. Protein Sci.