CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.140 | Metal-dependent hydrolases |
Domain Context
CATH Clusters
| Superfamily | Metal-dependent hydrolases |
| Functional Family | Cytosine deaminase |
Enzyme Information
| 3.5.4.1 |
Cytosine deaminase.
based on mapping to UniProt P25524
Cytosine + H(2)O = uracil + NH(3).
-!- Also acts on 5-methylcytosine.
|
| 3.5.4.- |
In cyclic amidines.
based on mapping to UniProt P25524
|
UniProtKB Entries (1)
| P25524 |
CODA_ECOLI
Escherichia coli K-12
Cytosine deaminase
|
PDB Structure
| PDB | 3G77 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo.
Cancer Res.
|
