CATH Classification

Domain Context

CATH Clusters

Superfamily Peptide deformylase
Functional Family Peptide deformylase

Enzyme Information

3.5.1.88
Peptide deformylase.
based on mapping to UniProt Q9HBH1
Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.
-!- Requires at least a dipeptide for an efficient rate of reaction. -!- N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. -!- Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.

UniProtKB Entries (1)

Q9HBH1
DEFM_HUMAN
Homo sapiens
Peptide deformylase, mitochondrial

PDB Structure

PDB 3G5K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and activity of human mitochondrial peptide deformylase, a novel cancer target
Escobar-Alvarez, S., Goldgur, Y., Yang, G., Ouerfelli, O., Li, Y., Scheinberg, D.A.
J.Mol.Biol.