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1 keywords

CATH Domain 3fw9A01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.43 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2
Homologous Superfamily 3.30.43.10 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2

Domain Context

CATH Clusters

Superfamily Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2
Functional Family

Enzyme Information

1.21.3.3
Reticuline oxidase.
based on mapping to UniProt P30986
(S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2).
-!- Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)- tetrahydroprotoberberines. -!- The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants. -!- Formerly EC 1.5.3.9.

UniProtKB Entries (1)

P30986
RETO_ESCCA
Eschscholzia californica
Reticuline oxidase

PDB Structure

PDB 3FW9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural roles of biocovalent flaninylation in berberine bridge enzyme
Winkler, A., Motz, K., Riedl, S., Puhl, M., Macheroux, P., Gruber, K.
to be published
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