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1 keywords

CATH Domain 3f9kS00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.930 Transcription Elongation Factor S-II; Chain A
Homologous Superfamily 1.20.930.10 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70

Domain Context

CATH Clusters

Superfamily Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
Functional Family PC4 and SFRS1-interacting protein-like isoform X1

Enzyme Information

UniProtKB Entries (2)

O75475
PSIP1_HUMAN
Homo sapiens
PC4 and SFRS1-interacting protein
P04584
POL_HV2RO
Human immunodeficiency virus type 2 (ISOLATE ROD)
Gag-Pol polyprotein

PDB Structure

PDB 3F9K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75
Hare, S., Shun, M.C., Gupta, S.S., Valkov, E., Engelman, A., Cherepanov, P.
Plos Pathog.
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