CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P19221
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P19221
THRB_MOUSE
Mus musculus
Prothrombin

PDB Structure

PDB 3EDX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin
Gandhi, P.S., Page, M.J., Chen, Z., Bush-Pelc, L., Di Cera, E.
To be Published