CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloenzyme, LuxS/M16 peptidase-like
Functional Family Putative insulin-degrading enzyme

Enzyme Information

3.4.24.56
Insulysin.
based on mapping to UniProt P14735
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.

UniProtKB Entries (1)

P14735
IDE_HUMAN
Homo sapiens
Insulin-degrading enzyme

PDB Structure

PDB 3E4A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Leissring, M.A., Malito, E., Hedouin, S., Reinstatler, L., Sahara, T., Abdul-Hay, S.O., Choudhry, S., Maharvi, G.M., Fauq, A.H., Huzarska, M., May, P.S., Choi, S., Logan, T.P., Turk, B.E., Cantley, L.C., Manolopoulou, M., Tang, W.J., Stein, R.L., Cuny, G.D., Selkoe, D.J.
Plos One