CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P08069
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08069
IGF1R_HUMAN
Homo sapiens
Insulin-like growth factor 1 receptor

PDB Structure

PDB 3D94
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
Wu, J., Li, W., Craddock, B.P., Foreman, K.W., Mulvihill, M.J., Ji, Q.S., Miller, W.T., Hubbard, S.R.
Embo J.